Prominent expression of acidic fibroblast growth factor in motor and sensory neurons
نویسندگان
چکیده
منابع مشابه
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas.
BACKGROUND/AIM Fibroadenomas are benign tumours composed of both glandular and fibrous tissue. The mechanisms regulating the growth of these tumours and the relation between the stromal and epithelial cells are poorly understood. Acidic fibroblast growth factor (aFGF) is a well known fibroblast activator, which acts through four specific cell surface receptors, among which, fibroblast growth fa...
متن کاملDifferentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development.
We have previously isolated and characterized acidic fibroblast growth factor (aFGF) from the embryonic chick brain. To analyze the expression of the gene encoding this growth factor a cDNA clone was isolated. The predicted amino acid sequence was found to be highly conserved (90%) between human and chick. Using single-stranded DNA probes, aFGF gene expression was detectable at day 3.5 in the e...
متن کاملAcidic fibroblast growth factor in the developing rat embryo
Compared to basic fibroblast growth factor (bFGF), a widely distributed, broad spectrum mitogen and mesoderm inducer, acidic fibroblast growth factor (aFGF) is reported to have an essentially neural distribution and to be undetectable in the early embryo. In the present investigation, we used immunoblotting and immunochemistry to assess the cellular and tissue distributions of aFGF and bFGF in ...
متن کاملMutagenesis of the crystal contact of acidic fibroblast growth factor
An attempt has been made to improve a crystal contact of human acidic fibroblast growth factor (haFGF; 140 amino acids) to control the crystal growth, because haFGF crystallizes only as a thin-plate form, yielding crystals suitable for X-ray but not neutron diffraction. X-ray crystal analysis of haFGF showed that the Glu81 side chain, located at a crystal contact between haFGF molecules, is in ...
متن کامل(Acidic and Basic Fibroblast) Growth Factor Gene Expression in Human Vascular Smooth Muscle Cells1
Vascular smooth muscle cell proliferation is regarded as a key early event in the pathogenesis of atherosclerosis. Heparin-binding growth factor (HBGF)1 and HBGF-2, also referred to as acidic and basic fibroblast growth factor, are potent mitogens for human vascular smooth muscle cells. These cells coexpress HBGF-1 and HBGF-2 and thus represent a vessel wall source for both polypeptides. In thi...
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ژورنال
عنوان ژورنال: Neuron
سال: 1991
ISSN: 0896-6273
DOI: 10.1016/0896-6273(91)90288-b